Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine
Identifieur interne : 001325 ( Main/Exploration ); précédent : 001324; suivant : 001326Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine
Auteurs : W. P. Tang [République populaire de Chine] ; P. G. Huang [République populaire de Chine] ; M. L. Zhao [République populaire de Chine] ; S. L. Liao [République populaire de Chine] ; Y. Zeng [République populaire de Chine]Source :
- Journal of Cancer Research and Clinical Oncology [ 0171-5216 ] ; 1988-08-01.
Abstract
Summary: Nasopharyngeal carcinoma was induced in an initiation/promotion model in rats by s.c. injection of dinitrosopiperazine in the nasopharyngeal cavity. This was followed by repeated 10-cal administration of an extract of roots of the Chinese medicinal herb WI (botanical family: Thymelaeaceae). Three groups of rats were used: group-1 received DNP followed by repeated WI; group-2 received DNP once; group-3 received WI repeatedly. At 180-205 days after DNP + WI administration 26% of the rats in that group exhibited NPC (two were carcinomas in situ and four were early infiltrating carcinomas). In the other two groups no carcinomas were found. In the group which received DNP followed by WI, other pathological changes, such as hyperplasia of nasopharyngeal epithelium, squamous metaplasia, and papillary hyperplasia, were also more frequent than that in the other two groups.
Url:
DOI: 10.1007/BF02128191
Affiliations:
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P." last="Tang">W. P. Tang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhangjiang Medical College, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Huang, P G" sort="Huang, P G" uniqKey="Huang P" first="P. G." last="Huang">P. G. Huang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhangjiang Medical College, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, M L" sort="Zhao, M L" uniqKey="Zhao M" first="M. L." last="Zhao">M. L. Zhao</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhangjiang Medical College, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Liao, S L" sort="Liao, S L" uniqKey="Liao S" first="S. L." last="Liao">S. L. Liao</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhangjiang Medical College, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zeng, Y" sort="Zeng, Y" uniqKey="Zeng Y" first="Y." last="Zeng">Y. Zeng</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Academy of Preventive Medicine, Institute of Virology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Cancer Research and Clinical Oncology</title><title level="j" type="abbrev">J Cancer Res Clin Oncol</title><idno type="ISSN">0171-5216</idno><idno type="eISSN">1432-1335</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1988-08-01">1988-08-01</date><biblScope unit="volume">114</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="429">429</biblScope><biblScope unit="page" to="431">431</biblScope></imprint><idno type="ISSN">0171-5216</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0171-5216</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Nasopharyngeal carcinoma was induced in an initiation/promotion model in rats by s.c. injection of dinitrosopiperazine in the nasopharyngeal cavity. This was followed by repeated 10-cal administration of an extract of roots of the Chinese medicinal herb WI (botanical family: Thymelaeaceae). Three groups of rats were used: group-1 received DNP followed by repeated WI; group-2 received DNP once; group-3 received WI repeatedly. At 180-205 days after DNP + WI administration 26% of the rats in that group exhibited NPC (two were carcinomas in situ and four were early infiltrating carcinomas). In the other two groups no carcinomas were found. In the group which received DNP followed by WI, other pathological changes, such as hyperplasia of nasopharyngeal epithelium, squamous metaplasia, and papillary hyperplasia, were also more frequent than that in the other two groups.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Tang, W P" sort="Tang, W P" uniqKey="Tang W" first="W. P." last="Tang">W. P. Tang</name></noRegion><name sortKey="Huang, P G" sort="Huang, P G" uniqKey="Huang P" first="P. G." last="Huang">P. G. Huang</name><name sortKey="Liao, S L" sort="Liao, S L" uniqKey="Liao S" first="S. L." last="Liao">S. L. Liao</name><name sortKey="Zeng, Y" sort="Zeng, Y" uniqKey="Zeng Y" first="Y." last="Zeng">Y. Zeng</name><name sortKey="Zhao, M L" sort="Zhao, M L" uniqKey="Zhao M" first="M. L." last="Zhao">M. L. 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